Quality of life among adolescents with epilepsy: An outpatient based study, Khartoum, Sudan

Main Article Content

Inaam N. Mohamed
Sarah E.Mohamed



Background The term “Quality of Life (QOL)” refers to the physical, psychological and social aspects of health. Several studies attempted to measure the QOL among epileptic patients using either generic or specific instruments. In adolescents the impact of epilepsy on life style and QOL is even more evident. The objective of this study is to measure the QOL and to identify the effect of gender, epilepsy classification, antiepileptic drugs (AEDs) and control of seizures on QOL in adolescent patients with epilepsy.


Methods This is a cross-sectional, observational study, conducted in outpatients at Gafer Ibn Auf Specialized Hospital and Soba University Hospital. Fifty patients were enrolled in the study and the QOL was measured using the tool Quality of Life in Epilepsy for Adolescents (QOLIE-AD-48). Data was analysed using statistical package for social sciences (SPSS).


Results The quality of Life total mean score for patients was 78.95±12.9. The highest mean score was for school behaviour domain (88.83±24.56) and the lowest score was for stigma (68.08±19.18).  Males with epilepsy had higher score for QOL as compared to females. Patients in basic school had significantly higher total QOL score than those in high school. The total score for QOL is significantly lower in patients with generalized-motor-tonic-clonic seizures, non-compliance to AEDs, on polytherapy and those with partial response to treatment (p  <0.05).


Conclusion Epilepsy has impact on quality of life in adolescents with epilepsy especially in the stigma and attitude towards the disease domains. Psychological evaluation and intervention are of great value to help patients cope with their illness. Transitional clinic to take over the care of adolescent patients for easy transfer to adulthood care is recommended.

Article Details

Original Articles


1. Stevanovic N, Tadic I. Health-related quality of life in children and adolescents with epilepsy: A systematic review, Epilepsy in children. International Journal of Advanced Robotic System 2011; 978:681-682.

2. Beilmann A, Napa A, Sööt A, Talvik I, Talvik T. Prevalence of childhood epilepsy in Estonia. Epilepsia 1999; 40:1011-9.

3. Hills MD. The psychological and social impact of epilepsy. Neurology Asia 2007; 12:10-2.

4. Ronen Streiner GDL, Rosenbaum P. Health- related quality of life in childhood epilepsy: moving beyond seizure control with minimal adverse effects. Health and Quality of Life Outcomes 2003; 1:36.

5. Berg AT, Berkovic SF, Brodie MJ, et al. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE commission on classification and terminology,
2005–2009. Epilepsia 2010; 51:676–685.

6. Fisher RS, Cross JH, French JA, et al.
Operational classification of seizure types by

the International League against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia
2017; 58:522-530.

7. Cramer JA, Westbrook L, Devinsky O, et al.
Development of a quality of life inventory for adolescents: The QOLIE-AD-48. Epilepsia
1999; 40: 1114-1121.

8. Ferro MA, Avison WR, Karen Campbell M, Speechley KN. The impact of maternal depressive symptoms on health‐related quality of life in children with epilepsy: A prospective study of family environment as mediators and moderators. Epilepsia 2011; 52:316-25.

9. Donnellan MB, Trzesniewski KH, Robins RW, Moffitt TE, Caspi A. Low self-esteem is related to aggression, antisocial behaviour and delinquency. Psychological Science 2005;

10. Diehl M, Hay EL, Risk and resilience factors in coping with daily stress in adulthood: The role of age, self-concept incoherence, and personal control. Developmental Psychology 2010;

11. McEwen MJ, Espie CA, Metcalfe J, Brodie MJ, Wilson MT. Quality of life and psychosocial development in adolescents with epilepsy: a qualitative investigation using focus group methods. Seizure 2004; 13:15-31.

12. Ferro MA, Ferro AL, Boyle MH. A systematic review of self-concept in adolescents with epilepsy. Journal of Paediatric Psychology
2012; 37:945-58.

13. Inaam N Mohamed, Hyder Babeker. Traditional and spiritual medicine among Sudanese patients with epilepsy. Sudanese Journal of Paediatrics
2013; 13: 31-37.

14. Herodes M, Qun A, Haldre S, Kaasik AE.
Epilepsy in Estonia: a quality-of-life study.
Epilepsia 2001; 42:1061-73.

15. Hills MD. The psychological and social impact

of epilepsy. Neurology Asia 2007; 12:10-2.

16. Spangenberg JJ, Lalkhen N. Children with epilepsy and their families: Psychosocial issues. South African Family Practice 2006; 48:60-3.

17. Frisen, A. Measuring health-related quality of
life in adolescence. Acta Paediatrica 2007; 96:

18. Wu D, Ding D, Wang Y, Hong Z. Quality of life and related factors in Chinese adolescents with active epilepsy. Epilepsy Research 2010;
90: 16–20.

19. Natha´lia F Siqueira, Fernando LBB. Oliveira Jorge A Siqueira, Elisabete Abib et al. Quality of Life in Epilepsy: A Study of Brazilian Adolescents. Plos One 2014; 9:e106879

20. Mohammad MS, Hemeida SA, Rabah AM.
Health status and quality of life in epileptic children and adolescents. Egypt J Neurol Psychiat Neurosurg 2010; 47:83-92.

21. Zamani G, Shiva S, Mohammadi M, Gharaie JM, Rezaei N. A survey of quality of life in adolescents with epilepsy in Iran. Epilepsy and Behaviour 2014; 33:69-72.

22. Devinsky O, Westbrook L, Cramer J, et al. Risk factors for poor health‐related quality of life in adolescents with epilepsy. Epilepsia 1999;

23. Gunawan P, Limanto T, Saharso D. Age decreases the quality of life in adolescents with intractable epilepsy correspondence. Universa Medicina 2015;34:104-111

24 Nagarathnam M, Shalini B, Vijayalakshmi V, Vengamma B, Latheef SA. Predictors of quality of life among adolescents with epilepsy in the state of Andhra Pradesh. Neurology India 2017;

25. Orrin Devinsky, Lauren Westbrook, Joyce Cramer, et al. Risk Factors for poor health- related quality of life in adolescents with epilepsy. Epifepsia 1999; 40: I715- 1720.

26. Abbas Z, Elseed MA, Mohammed IN. The quality of life among Sudanese children with epilepsy and their care givers. Sudanese Journal of Paediatrics 2014;14:51-9.

27. Leonardi M, Ustun T, The global burden of epilepsy. Epilepsia 2002;43:21-25

28, Sidenvall R, Forsgren L, Heijbel J. Prevalence and characteristics of epilepsy in children in northern Sweden. Seizure-European. Journal of Epilepsy 1996; 5:139-46.

29. Ziegler RG, Erba G, Holden L. Dennison H.
The coordinated psychosocial and neurologic care of children with seizures and their families. Epilepsia 2000; 41:732-43.

30. Smith ML, Elliott IM, Lach L. Cognitive skills in children with intractable epilepsy: comparison of surgical and nonsurgical candidates. Epilepsia 2002; 43:631-7.

31. Høie B, Sommerfelt K, Waaler PE, et al.
Psychosocial problems and seizure‐related factors in children with epilepsy. Developmental Medicine and Child Neurology 2006; 48:213-9.