Main Article Content
Spontaneous regression of malignant tumours is extremely rare. A 75 years old female patient presented to
Soba university hospital with sub acute intestinal obstruction. She had an adenocarcinoma of the small bowel
with proven liver metastasis. Resection and anastomosis was done and a biopsy of one nodule from the liver
showed metastatic lesion. The patient has been on regular follow-up for the last four years. At present she is
clinically well. A series of abdominal U/S showed disappearance of the metastatic liver tumour, suggesting that
spontaneous regression of metastatic liver tumour might have occurred.
1. Everson TC, Cole WH. Spontaneous regression of
cancer. WB Saunders, Philadelphia, PA 1966;560
2. Boyd W. The spontaneous regression of cancer.
Charles C. Thomas, Springfield, Illinois 1966;99
3. Challis GB, Stam HJ. The spontaneous regression
of cancer. A review of cases from 1900 to 1987.
Acta Oncl 1990; 29: 545-550 .
4. Kaiser HE, Bodey B Jr, Siegel SE, Groger AM,
Bodey B. Spontaneous neoplastic regression: the
significance of apoptosis. In vivo 2000; 14:773788.
5. Cole WH. Spontaneous regression of cancer the
metabolic triumph of the host. Ann N Y Acad Sci
1974; 230: 111-141
6. Everson TC. Spontaneous regression of
cancer. Annals of the New York Academy of
7. Ayman S. Abdelrazeq. Spontaneous regression of
colorectal cancer: a review of cases from 1900 to
2005. Int J Colorectal Dis 2007; 22: 727-736.
8. Salloum E, Cooper DL, Howe G, et al.
Spontaneous regression of lymphoproliferative
disorders in patients treated with methotrexate for
rheumatoid arthritis and other rheumatic disease.
J Clin Oncol 1996; 14:1943-1949
9. Penn I. Cancers complicating organ transplant.
N Engl J Med1990; 323:1767-1769
10. Viraben R, Brousse P, lament L. Reversible
cutaneous lymphoma occurring during
methotrexate therapy. Br J Dermatol 1996;
11. Malkovska V, Sondel PM, Malkovsky M.
Tumour immunotherapy. Curr Opin Immunol
12. Dao TL. Regression of pulmonary metastases of
a breast cancer. Arch Surg 1962; 84:574-577
13. Gohji K, Kizaki T, Fujii A. Spontaneous
regression of pulmonary metastases from
nonfuctionining adernocortical carcinoma after
removal of the primary lesion: a case report. J
Urol 1995; 154:1854-1855
14. Sindelar WF. Regression of cancer following
surgery. Natl Canver Inst Monogr 1976; 44:8188
15. Nauts HC , Swift WE, Coley BL. The treatment
of malignant tumours by bacterial toxins, as
developed by the late William B Coley, M.D.,
review in light of modern research. Cancer Res
1946; 6: 205-216
16. Balkwill FR, Naylor MS, Malik S. Tumour
necrosis factor as an anticancer agent. Eur J
Cancer 1990; 26:641-644
17. Stephenson HE Jr, Delmez JA, Renden DI, et
al. Host immunity and spontaneous regression of
cancer evaluated by computerized data reduction
study. Surg Gyneol Obstet 1971; 133:649-655
18. Takita H. Effect of postoperative empyema on
survival of patients with broncogenic carcinoma.
J Thorac Cardiovasc Surg 1970; 59:642-668
19. Alexander P. Some immunologically based
reactions that can cause the regression of large
tumour, mass. Natl Cancer Inst Monogr 1976;
20. Folkman J. What is the evidence that tumours
are angiogenesis dependent. J Natl Cancer Inst