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AbstractAbstractObjectives: This study was designed to asses the prevalence and characteristics of smoking and alcohol drinking among diabetics and non diabetics in Sudan, in addition to evaluation of the relation between thesefactors and major lower extremity amputation (LEA) in diabetics and the role of smoking cessation on the risk of major LEA. Methods: This is a case control study which included 65 male diabetics who had major LEA as cases, 110 diabetics and 110 non diabetics as control groups. A major LEA was defined as any Below Knee Amputation (BKA) or proximal. Results: There was a strongly significant association between smoking >10 cig/d and amputation compared with those who smoked < 10 cig/d. The same significant association was noticed between cumulative smokers of > 20 pack-years versus < 20 pack-years and never smokers. 66.7% of the amputees were heavy alcohol drinkers (200g/week) versus 55.8% of the diabetic controls, O.R 1.59, 95% CI 0.49-5.24, (P=0.55).Conclusion: Cigarette smoking is associated, in a dose response manner, with the rate of amputation. Alcoholdrinking did not show a statistically significant relation to amputation in diabetics.
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